SideFX Houdini: Proxy 3D model of the room was used as a collider for a two-emitter FLIP simulation.
Adobe After Effects: Composite and color the beer and blood simulation into the live action plate.
ANIMATION
Autodesk Maya: Animate CG insect models on an image sequence plane of live action reference plate.
Adobe After Effects: Composite and color the insect animation into live action clean plate.